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Introduction to 2-FDCK

2-FDCK (2-Fluorodeschloroketamine), also known as 2-Fluoroketamine or 2-Fl-2′-Oxo-PCM, is a synthetic dissociative compound belonging to the arylcyclohexylamine class . It is a structural analogue of the well-known anaesthetic ketamine, distinguished by the substitution of the chlorine atom with a fluorine atom at the 2-position of the phenyl ring . This chemical modification produces a compound with a distinct pharmacological profile, including a potentially longer duration of action due to altered metabolic pathways .

As a research chemical, 2-FDCK is primarily utilized as a certified reference material for forensic and analytical applications. The World Health Organization’s Expert Committee on Drug Dependence (ECDD) has reviewed 2-FDCK and recommended its addition to Schedule II of the Convention on Psychotropic Substances of 1971 . At 4mmcchems, we supply premium-grade 2-FDCK to researchers and professionals worldwide, with a focus on fast, discreet shipping across Europe.

Product Specifications

Product Name: 2-FDCK (2-Fluorodeschloroketamine)

Synonyms: 2-Fluoroketamine, 2-Fl-2′-Oxo-PCM, 2-FDCK

CAS Number: 111982-49-1 (hydrochloride salt); 111982-50-4 (free base)

Molecular Formula: C₁₃H₁₇ClFNO (hydrochloride salt)

Molecular Weight: 257.73 g/mol (hydrochloride salt)

Purity: ≥ 98% (verified by third-party HPLC/GC-MS testing)

Form: Crystalline solid or white powder

Storage: -20°C for long-term stability

Availability: In stock, ready for immediate dispatch

Chemical Properties and Mechanism of Action

2-FDCK acts primarily as an NMDA receptor antagonist, a mechanism it shares with ketamine and other arylcyclohexylamines . This interaction with the NMDA receptor produces dissociative, hallucinogenic, and related effects in research models .

Key Pharmacological Data

• Mechanism: NMDA receptor antagonist with additional activity at dopamine, serotonin, GABA, norepinephrine, and acetylcholine receptors

• Potency: User reports indicate 2-FDCK may be more potent than ketamine, with effects potentially lasting longer due to slower metabolism

• Half-Life: Approximately 69 minutes, compared to ketamine’s shorter duration

• Metabolism: The primary metabolic pathway is N-dealkylation, producing nor-2-FDCK as the major metabolite. The fluorine atom reduces CYP2B6 affinity, resulting in slower metabolization and prolonged effects compared to ketamine

Research Applications

2-FDCK is valuable for studying NMDA receptor dynamics, structure-activity relationships within the arylcyclohexylamine class, and comparative pharmacology of dissociative compounds . It also serves as an analytical reference standard for identifying this compound in forensic samples, with validated methods available for detection in biological matrices including blood, urine, and hair .

Why Choose 4mmcchems?

1. Uncompromising Quality

We source our 2-FDCK from certified manufacturers with strict adherence to Good Manufacturing Practice (GMP) guidelines. Every batch undergoes independent HPLC and GC-MS testing to guarantee purity and potency, meeting the ≥98% purity threshold required for analytical reference materials.

2. Discreet and Secure Packaging

Your privacy is paramount. All orders are shipped in plain, unbranded packaging with no external markings indicating contents. Tamper-evident seals ensure security throughout transit.

3. Worldwide Shipping with European Focus

4mmcchems operates a robust global logistics network. We offer fast, reliable shipping to customers worldwide, with a particular emphasis on European markets:

• European Shipping: 2-FDCK has been detected in 22 EU Member States and is controlled in at least five . France classified 2-FDCK as a narcotic in August 2024 . We have optimized shipping routes to ensure timely delivery to all EU member states, the UK, Switzerland, and more.

• Fast Transit Times: Typical delivery to European destinations ranges from 3 to 7 business days.

• Tracking Provided: Every order comes with a tracking number for real-time shipment monitoring.

4. Competitive Pricing and Bulk Discounts

We offer tiered pricing for bulk orders, making 4mmcchems the cost-effective choice for large-scale research projects. Contact our sales team for custom quotes.

5. Responsive Customer Support

Our knowledgeable team is available to answer queries regarding product specifications, shipping, and order status. We prioritize clear and prompt communication.

Safety and Regulatory Information

2-FDCK is a regulated substance in many jurisdictions. The WHO ECDD has recommended its addition to Schedule II of the 1971 Convention on Psychotropic Substances, citing sufficient evidence of abuse potential and public health risk . The European Union has adopted a position supporting international control of 2-FDCK .

Documented Health Risks

2-FDCK has been associated with serious adverse events including:

• Neurological: Dissociation, confusion, agitation, combativeness, hallucinations, impaired consciousness, and loss of consciousness

• Cardiovascular: Tachycardia and hypertension

• Fatalities: At least one documented death involving 2-FDCK alone, with additional fatalities reported in combination with other substances

• French Addictovigilance Data (2017-2023): 39 cases of adverse effects reported, with 66% judged severe, including 13 hospitalizations, 10 emergency department visits, and 4 intensive care admissions

Important Considerations for Researchers:

• Controlled Status: 2-FDCK is subject to international control recommendations and is controlled in multiple EU member states. It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.

• Research Use Only: This product is intended for research, forensic, and analytical applications only. Not for human or veterinary use .

• Handling Precautions: Standard laboratory safety protocols should be followed when handling this compound. Given its documented toxicity and association with fatalities, appropriate personal protective equipment (PPE) is recommended.

Shipping Information: Worldwide Delivery

4mmcchems is committed to making our products accessible globally. We ship to all major regions, including:

• Europe: All EU member states, UK, Switzerland, Norway, and more.

• North America: USA, Canada, Mexico.

• Asia: Japan, South Korea, Singapore, China, India, and others.

• Australia & Oceania

• South America

• Middle East & Africa

Shipping Methods:

• Standard Air Mail (7-21 days, tracking available)

• Express Courier (3-7 days, fully tracked, signature required)

Customs and Duties: Customers are responsible for any customs duties or import taxes applicable in their country. We provide all necessary documentation to facilitate smooth customs clearance, subject to local regulations.